Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557563 | 0.86 | DRD1 (0.31) | DRD1SPR | |
| SCHEMBL3813237 | 0.86 | GRM5 (0.33) | SPR | |
| SCHEMBL3810606 | 0.86 | PARP1 (0.36) | DRD1SPR | |
| SCHEMBL4558566 | 0.84 | PRMT5 (0.34) | DRD1CYP3A4HTR2BCACNA1B | |
| SCHEMBL3821854 | 0.84 | GRM5 (0.31) | — | |
| SCHEMBL3812986 | 0.84 | MAPK1 (0.34) | DRD1SPR | |
| SCHEMBL3820638 | 0.84 | DRD1 (0.43) | DRD1CYP3A4HTR2BCACNA1B | |
| SCHEMBL3819025 | 0.84 | DRD1 (0.40) | DRD1CYP3A4HTR2BCACNA1B | |
| SCHEMBL4078137 | 0.83 | GRM5 (0.36) | SPR | |
| SCHEMBL3816095 | 0.83 | PARP1 (0.36) | DRD1CYP3A4HTR2BCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |