Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1533665 | 0.82 | PARP1 (0.54) | KDM4EMEN1KMT2ABCAT2ALDH1A1 | |
| SCHEMBL6616377 | 0.74 | BCAT2 (0.47) | KDM4EMEN1KMT2ABCAT2ALDH1A1 | |
| SCHEMBL29002505 | 0.73 | KDM4E (0.53) | KDM4EMEN1KMT2ABCAT2ALDH1A1 | |
| SCHEMBL4782645 | 0.73 | BCAT2 (0.46) | KDM4EMEN1KMT2ABCAT2ALDH1A1 | |
| SCHEMBL11901439 | 0.73 | SIRT2 (0.64) | SIRT2KDM4EKMT2ABCAT2PLA2G2A | |
| SCHEMBL2402498 | 0.71 | KDM4E (0.57) | SIRT2KDM4EMEN1KMT2APLA2G2A | |
| SCHEMBL4504523 | 0.70 | JAK2 (0.49) | KDM4EMEN1KMT2ABCAT2ALDH1A1 | |
| Carbamic Acid SCHEMBL2222080 | 0.69 | FFAR1 (0.62) | PLA2G2APLA2G10ALDH1A1NOS1 | |
| Urea SCHEMBL2006220 | 0.69 | FFAR1 (0.62) | PLA2G2APLA2G10ALDH1A1NOS1 | |
| SCHEMBL11818086 | 0.68 | KCNH2 (0.66) | KCNH2KDM4EDHFRALDH1A1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | KCNH2 2433/4885SIRT2 47/4885KDM4E 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.