Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561031 | 0.87 | TP53 (0.54) | ALDH1A1SMN1; SMN2LMNATP53ALOX5 | |
| SCHEMBL4558972 | 0.85 | LMNA (0.47) | ALDH1A1SMN1; SMN2LMNATP53ALOX5 | |
| SCHEMBL4558955 | 0.85 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNATP53ALOX5 | |
| SCHEMBL12821356 | 0.84 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2LMNATP53APAF1 | |
| SCHEMBL22406302 | 0.82 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNATP53APAF1 | |
| SCHEMBL8922653 | 0.82 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNATP53APAF1 | |
| SCHEMBL5696562 | 0.82 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2LMNATP53ALOX5 | |
| SCHEMBL27599780 | 0.81 | LMNA (0.46) | ALDH1A1SMN1; SMN2LMNATP53APAF1 | |
| SCHEMBL4674910 | 0.81 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATP53APAF1 | |
| SCHEMBL26029270 | 0.81 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATP53APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | ALDH1A1 532/4885SMN1; SMN2 3638/4885LMNA 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.