Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284685 | 0.84 | MAPT (0.50) | ALDH1A1MAPTL3MBTL1KMT2ALMNA | |
| SCHEMBL10606669 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTL3MBTL1KMT2ANPBWR1 | |
| SCHEMBL11040887 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MAPTL3MBTL1KMT2ANPBWR1 | |
| SCHEMBL1848362 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MAPTL3MBTL1KMT2ALMNA | |
| SCHEMBL4560587 | 0.78 | MAPT (0.44) | ALDH1A1MAPTL3MBTL1KMT2ANPBWR1 | |
| SCHEMBL20318842 | 0.75 | ALDH1A1 (0.50) | ALDH1A1MAPTL3MBTL1LMNAGAA | |
| SCHEMBL7193484 | 0.74 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1KMT2ALMNA | |
| SCHEMBL4560585 | 0.73 | TDP1 (0.42) | ALDH1A1MAPTL3MBTL1KMT2ALMNA | |
| SCHEMBL277291 | 0.73 | TSHR (0.30) | TSHR | |
| SCHEMBL489425 | 0.72 | MAPT (0.47) | ALDH1A1MAPTL3MBTL1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560460-B2 | Substituted piperazines and methods of use | AMGEN INC. (US) | 2009-07-14 | — | — | US | claimed |