Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284685 | 0.89 | MAPT (0.50) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL1848362 | 0.83 | ALDH1A1 (0.47) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL10606669 | 0.82 | ALDH1A1 (0.57) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL11040887 | 0.81 | ALDH1A1 (0.55) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL998994 | 0.79 | MAPT (0.67) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL11518220 | 0.79 | MAPT (0.67) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL4560586 | 0.78 | ALDH1A1 (0.42) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL31008679 | 0.77 | ALDH1A1 (0.30) | ALDH1A1KMT2ACYP2C19MEN1 | |
| SCHEMBL11042965 | 0.77 | MAPT (0.48) | MAPTALDH1A1L3MBTL1KMT2ATDP1 | |
| SCHEMBL7193484 | 0.76 | ALDH1A1 (0.52) | MAPTALDH1A1L3MBTL1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560460-B2 | Substituted piperazines and methods of use | AMGEN INC. (US) | 2009-07-14 | — | — | US | claimed |