Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | PPID | Q08752 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30354719 | 1.00 | PDCD1 (0.55) | PDCD1CD274SMN1; SMN2MMP8PPID | |
| Hydrochloric Acid SCHEMBL29935507 | 0.98 | PDCD1 (0.54) | PDCD1CD274SMN1; SMN2MMP8PPID | |
| SCHEMBL13915549 | 0.88 | MMP8 (0.56) | SMN1; SMN2MMP8PPIDEPHX2PPARG | |
| SCHEMBL1931193 | 0.88 | MMP8 (0.56) | SMN1; SMN2MMP8PPIDEPHX2PPARG | |
| SCHEMBL14636601 | 0.87 | ATM (0.56) | PDCD1CD274MAPTMEN1KMT2A | |
| SCHEMBL304265 | 0.87 | ATM (0.56) | PDCD1CD274MAPTMEN1KMT2A | |
| SCHEMBL5878196 | 0.87 | ATM (0.56) | PDCD1CD274MAPTMEN1KMT2A | |
| SCHEMBL1781525 | 0.86 | SMN1; SMN2 (0.49) | PDCD1CD274SMN1; SMN2MMP8PPID | |
| SCHEMBL14265369 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2MMP8PPIDEPHX2PPARG | |
| SCHEMBL30988969 | 0.86 | SMN1; SMN2 (0.49) | PDCD1CD274SMN1; SMN2MMP8PPID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113461668-B | Novel biphenyl derivative, preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2022-12-09 | — | — | CN | claimed |
| US-20050261372-A1 | Derivatives of glycinergic r(+)-2-amino-3-hydroxypropanoic acid | ORAPHARMA, INC. | 2005-11-24 | — | — | US | claimed |
| CN-117561246-A | Novel biphenyl derivative, preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-111909108-B | Biphenyl compound and preparation method and medical application thereof | 中国药科大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-113773273-B | Benzisothiazole compound, preparation method and application thereof | 沈阳药科大学 | 2023-04-11 | — | — | CN | disclosed |
| CN-113461668-B | Novel biphenyl derivative, preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| US-7488755-B2 | Derivatives of glycinergic R(+)-2-amino-3-hydroxypropanoic acid | PRESTWICK PHARMACEUTICALS, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-20050261372-A1 | Derivatives of glycinergic r(+)-2-amino-3-hydroxypropanoic acid | ORAPHARMA, INC. | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261372-A1 | Derivatives of glycinergic r(+)-2-amino-3-hydroxypropanoic acid | GLRA3, GLRA1, GLRA2 | PDCD1 4863/4885CD274 4870/4885SMN1; SMN2 825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.