Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 11/20 | 0.50 |
| ▸ | JAK3 | P52333 | 10/20 | 0.50 |
| ▸ | JAK1 | P23458 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561292 | 0.89 | ALDH1A1 (0.46) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL4561894 | 0.86 | JAK3 (0.46) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL4561973 | 0.86 | JAK2 (0.44) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL4562626 | 0.86 | ALDH1A1 (0.45) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL4561182 | 0.86 | JAK1 (0.52) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL4561529 | 0.85 | ALDH1A1 (0.46) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL4562639 | 0.85 | JAK1 (0.53) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL4562570 | 0.85 | IGF1R (0.48) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL4561201 | 0.85 | KDM4E (0.43) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL4562265 | 0.84 | KDM4E (0.43) | JAK2JAK3JAK1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |