Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 6/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982288 | 1.00 | PLK1 (0.41) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL14568212 | 0.96 | PLK1 (0.39) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL13592940 | 0.96 | PLK1 (0.39) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2973849 | 0.94 | AKR1C3 (0.41) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2973853 | 0.94 | AKR1C3 (0.41) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2986971 | 0.91 | PLK1 (0.41) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL5582470 | 0.89 | AKR1B10 (0.39) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2982204 | 0.89 | AKR1B10 (0.39) | PLK1PLK3AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL13592925 | 0.89 | AKR1B10 (0.39) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL2987859 | 0.88 | PLK1 (0.44) | PLK1PLK3TP53RXFP1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-B1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORP (US) | 2009-12-30 | — | — | EP | disclosed |