Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5673498 | 0.83 | SMN1; SMN2 (0.36) | ALDH1A1MEN1HPGDKMT2ARAB9A | |
| SCHEMBL455756 | 0.77 | MAPK1 (0.42) | ALDH1A1METAP2AXLMKNK1MKNK2 | |
| SCHEMBL453941 | 0.77 | — | — | |
| SCHEMBL4861987 | 0.76 | GSK3B (0.43) | MAPTLMNANPC1RAB9A | |
| SCHEMBL4703629 | 0.75 | HPGD (0.38) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| SCHEMBL5500501 | 0.73 | SMN1; SMN2 (0.38) | ALDH1A1MEN1HPGDKMT2ARAB9A | |
| SCHEMBL4704287 | 0.72 | MAPT (0.43) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| SCHEMBL11097956 | 0.71 | SSTR1 (0.43) | ALDH1A1MEN1KMT2ARAB9AMAOA | |
| SCHEMBL7056243 | 0.70 | TSHR (0.54) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| SCHEMBL5004823 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613630-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Cempra Pharmaceuticals, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034058-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2012-03-15 | — | — | WO | disclosed |