Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.49 |
| ▸ | JAK3 | P52333 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.45 |
| ▸ | STAT3 | P40763 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562331 | 0.93 | JAK2 (0.49) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4562163 | 0.92 | CDK1 (0.43) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4561892 | 0.88 | JAK2 (0.51) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL5021903 | 0.88 | ALDH1A1 (0.45) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4561965 | 0.85 | JAK3 (0.49) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL5021905 | 0.85 | JAK2 (0.57) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL27935907 | 0.85 | JAK2 (0.52) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4559528 | 0.83 | CDK1 (0.43) | JAK2JAK3JAK1TYK2STAT3 | |
| SCHEMBL4561206 | 0.82 | JAK2 (0.45) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4560697 | 0.81 | JAK2 (0.47) | JAK2JAK3HDAC1HDAC6JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | claimed |
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | disclosed |