Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3106090 | 1.00 | TYK2 (0.36) | TYK2HTR2COPRM1CXCR1CXCR2 | |
| SCHEMBL3120023 | 1.00 | TYK2 (0.36) | TYK2HTR2COPRM1CXCR1CXCR2 | |
| SCHEMBL3118605 | 0.91 | HTR2C (0.36) | TYK2HTR2CCXCR1CXCR2HCRTR1 | |
| SCHEMBL3119013 | 0.91 | TYK2 (0.36) | TYK2HTR2CCXCR1CXCR2JAK2 | |
| SCHEMBL3118823 | 0.86 | HTR2C (0.39) | HTR2CJAK2 | |
| SCHEMBL3120159 | 0.83 | JAK2 (0.39) | JAK2POLB | |
| SCHEMBL3116932 | 0.83 | RAB9A (0.42) | TYK2JAK2KMT2AHCRTR1HCRTR2 | |
| SCHEMBL3120948 | 0.83 | RAB9A (0.42) | TYK2JAK2KMT2AHCRTR1HCRTR2 | |
| SCHEMBL3114743 | 0.79 | TYK2 (0.34) | TYK2HTR2CCXCR1CXCR2HCRTR1 | |
| SCHEMBL4562849 | 0.79 | TYK2 (0.34) | TYK2HTR2CCXCR1CXCR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099805-A2 | NOVEL AMINOTHIENOPYRIDINONE DERIVATIVES PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THEREOF | UCB Pharma S.A. (BE) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064829-A2 | NOVEL AMINOTHIENOPYRIDINONE DERIVATIVES PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THEREOF | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | disclosed |