Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257596 | 0.78 | NPC1 (0.65) | ALDH1A1ALOX15HTTNPC1POLB | |
| SCHEMBL5307795 | 0.77 | JAK2 (0.47) | ALDH1A1NPC1MAPTMEN1KMT2A | |
| SCHEMBL4437551 | 0.73 | EIF2AK4 (0.42) | ABL1AXLSRCALDH1A1ALOX15 | |
| SCHEMBL29396477 | 0.72 | ABL1 (0.67) | ABL1AXLSRCEPHB4PTK2 | |
| SCHEMBL28700821 | 0.72 | ABL1 (0.67) | ABL1AXLSRCEPHB4PTK2 | |
| SCHEMBL6817067 | 0.72 | NAMPT (0.61) | ALDH1A1ALOX15HTTNPC1POLB | |
| SCHEMBL2027842 | 0.72 | ABL1 (0.64) | ABL1AXLSRCEPHB4PTK2 | |
| SCHEMBL27402310 | 0.71 | ALOX15 (0.50) | ALDH1A1ALOX15HTTNPC1POLB | |
| SCHEMBL30905555 | 0.71 | ALOX15 (0.50) | ALDH1A1ALOX15HTTNPC1POLB | |
| SCHEMBL4563006 | 0.71 | PDE10A (0.42) | ABL1AXLSRCALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073811-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008046003-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-04-17 | — | — | WO | disclosed |