Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053394 | 0.77 | TP53 (0.44) | NPC1ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL27676108 | 0.76 | SOAT2 (0.52) | NPC1ALDH1A1KDM4EPOLBTP53 | |
| SCHEMBL27742973 | 0.76 | KDM4E (0.39) | NPC1ALDH1A1KDM4ETLR8TLR7 | |
| SCHEMBL5266895 | 0.75 | CYP2C9 (0.44) | NPC1ALDH1A1KDM4EHTTTP53 | |
| SCHEMBL28784326 | 0.75 | SOAT2 (0.41) | NPC1ALDH1A1KDM4ETLR8TLR7 | |
| SCHEMBL27678180 | 0.74 | OXTR (0.44) | NPC1ALDH1A1KDM4EHTTTP53 | |
| SCHEMBL4563007 | 0.73 | ABL1 (0.48) | PDE10ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL9453146 | 0.72 | SOAT1 (0.58) | NPC1ALDH1A1KDM4EPOLBTP53 | |
| SCHEMBL11086699 | 0.71 | SOAT1 (0.60) | NPC1ALDH1A1KDM4ETP53RAB9A | |
| SCHEMBL27463663 | 0.71 | CYP1A2 (0.34) | NPC1ALDH1A1KDM4ETLR8TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073811-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008046003-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-04-17 | — | — | WO | disclosed |