Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.61 |
| ▸ | HTR6 | P50406 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MC5R | P33032 | 2/20 | 0.51 |
| ▸ | MC3R | P41968 | 2/20 | 0.51 |
| ▸ | MC1R | Q01726 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL4563646 | 0.92 | HTR6 (0.61) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| SCHEMBL8289901 | 0.89 | HDAC1 (0.76) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| SCHEMBL4563301 | 0.89 | HDAC1 (0.60) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| Hydroxyamine SCHEMBL4563582 | 0.83 | KMT2A (0.59) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| Hydroxyamine SCHEMBL4563390 | 0.81 | KMT2A (0.64) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| SCHEMBL4553062 | 0.81 | HTR6 (0.62) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| SCHEMBL8288741 | 0.81 | HDAC1 (0.70) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| SCHEMBL4563645 | 0.81 | HTR6 (0.56) | HDAC1HTR6KMT2AHDAC3HDAC4 | |
| SCHEMBL8290074 | 0.80 | ACKR3 (0.60) | HDAC1KMT2ARAB9AMEN1 | |
| SCHEMBL23745517 | 0.79 | MC5R (0.71) | HDAC1HTR6KMT2AHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682538-A4 | BIARYL LINKED HYDROXAMATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S BIO PTE LTD (SG) | 2009-05-27 | — | — | EP | claimed |
| EP-1682538-A1 | BIARYL LINKED HYDROXAMATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S*Bio Pte Ltd (SG) | 2006-07-26 | — | — | EP | claimed |
| WO-2005040161-A1 | BIARYL LINKED HYDROXAMATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S*BIO PTE LTD (SG) | 2005-05-06 | — | — | WO | claimed |