SCHEMBL4563304

SCHEMBL4563304

CC(C)OC(=O)N1CCC(Oc2cc(Nc3ccc(S(C)(=O)=O)cc3)nc([N+](=O)[O-])n2)CC1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.60
CYP2C9 P11712 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL386797 0.84 GPR119 (0.77) GPR119CYP2C9
SCHEMBL4449317 0.77 GPR119 (0.58) GPR119
SCHEMBL388644 0.77 GPR119 (0.63) GPR119CYP2C9
SCHEMBL386487 0.76 GPR119 (0.78) GPR119CYP2C9
SCHEMBL2551953 0.72 GPR119 (0.75) GPR119
SCHEMBL12283010 0.72 GPR119 (0.75) GPR119
SCHEMBL4722464 0.72 GPR119 (0.60) GPR119CYP2C9
SCHEMBL288892 0.72 GPR119 (1.00) GPR119CYP2C9
SCHEMBL389852 0.72 GPR119 (0.79) GPR119CYP2C9
SCHEMBL390044 0.70 GPR119 (0.63) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1758565-B2 Method of identifying GLP-1 secretagogues ARENA PHARM INC (US) 2012-11-14 EP disclosed
EP-1758565-B1 Method of identifying GLP-1 secretagogues ARENA PHARM INC (US) 2009-05-13 EP disclosed