Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9981108 | 0.82 | DAO (0.58) | KDM4EALDH1A1HPGDDAOMAPK1 | |
| SCHEMBL3311126 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1DAOADORA3ADORA2A | |
| SCHEMBL30970867 | 0.78 | ADORA3 (0.62) | ALDH1A1HPGDDAOHSD17B10ADORA3 | |
| SCHEMBL4316407 | 0.77 | FEN1 (0.60) | KDM4EALDH1A1HPGDDAOSMN1; SMN2 | |
| SCHEMBL28985781 | 0.77 | ADORA3 (0.48) | KDM4EDAOADORA3ADORA2AADORA1 | |
| SCHEMBL30394101 | 0.77 | ADORA3 (0.48) | KDM4EDAOADORA3ADORA2AADORA1 | |
| SCHEMBL11868273 | 0.76 | ADORA3 (0.53) | KDM4EALDH1A1HPGDHSD17B10ADORA3 | |
| SCHEMBL3311524 | 0.76 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL7022436 | 0.74 | DAO (0.41) | KDM4EALDH1A1HPGDDAOADORA3 | |
| SCHEMBL7022440 | 0.74 | DAO (0.41) | KDM4EALDH1A1HPGDDAOADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132186-A1 | BICYCLIC ORGANIC COMPOUNDS SUITABLE FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS | Novartis AG (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008107436-A1 | BICYCLIC ORGANIC COMPOUNDS SUITABLE FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS | NOVARTIS AG (CH) | 2008-09-12 | — | — | WO | disclosed |