Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 8/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 8/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19404905 | 0.81 | SMN1; SMN2 (0.57) | JAK2JAK1SMN1; SMN2TYK2JAK3 | |
| SCHEMBL29087342 | 0.81 | SMN1; SMN2 (0.59) | BCL9CTNNB1JAK2JAK1SMN1; SMN2 | |
| SCHEMBL5552182 | 0.80 | SMN1; SMN2 (0.46) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1434918 | 0.80 | SMN1; SMN2 (0.46) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL25035422 | 0.78 | SMN1; SMN2 (0.59) | JAK2JAK1SMN1; SMN2TYK2JAK3 | |
| SCHEMBL4398722 | 0.78 | SMN1; SMN2 (0.59) | JAK2JAK1SMN1; SMN2TYK2JAK3 | |
| SCHEMBL13963379 | 0.78 | SMN1; SMN2 (0.59) | JAK2JAK1SMN1; SMN2TYK2JAK3 | |
| SCHEMBL4968602 | 0.78 | PDE4B (0.55) | BCL9CTNNB1JAK2JAK1SMN1; SMN2 | |
| SCHEMBL5368396 | 0.77 | SMN1; SMN2 (0.60) | JAK2JAK1SMN1; SMN2TYK2JAK3 | |
| SCHEMBL6128832 | 0.77 | SMN1; SMN2 (0.60) | JAK2JAK1SMN1; SMN2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125829-A2 | BICYCLIC OXOMORPHOLINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008108378-A2 | BICYCLIC OXOMORPHOLINE DERIVATIVE | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-12 | — | — | WO | disclosed |