Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MAP2 | P11137 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643564 | 0.84 | ALDH1A1 (0.49) | KMT2ALMNAMEN1KDM4EGAA | |
| SCHEMBL3695771 | 0.81 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL4069744 | 0.80 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL31196064 | 0.80 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL8050330 | 0.74 | KDM4E (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL15557355 | 0.70 | KDM4E (0.54) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL24196769 | 0.67 | KDM4E (0.45) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL21465529 | 0.67 | KMT2A (0.56) | KMT2ALMNAMEN1KDM4EGAA | |
| SCHEMBL386416 | 0.67 | MAP2 (0.53) | KMT2ALMNAMEN1KDM4EGAA | |
| SCHEMBL832441 | 0.67 | KDM4E (0.48) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040546-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007149427-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-27 | — | — | WO | disclosed |