SCHEMBL4564377

SCHEMBL4564377

C=CCc1ccc(C(C)=S)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
CYP3A4 P08684 4/20 0.48
TP53 P04637 1/20 0.48
ALOX15 P16050 1/20 0.48
TSHR P16473 1/20 0.48
ALOX12 P18054 1/20 0.48
XDH P47989 1/20 0.44
KMT2A Q03164 4/20 0.42
MEN1 O00255 3/20 0.42
MAPT P10636 3/20 0.42
PPARG P37231 2/20 0.42
PPARD Q03181 2/20 0.42
GABRA1 P14867 2/20 0.42
GABRB2 P47870 2/20 0.42
KDM4E B2RXH2 2/20 0.42
GAA P10253 2/20 0.42
ALDH2 P05091 1/20 0.42
AKR1B1 P15121 1/20 0.42
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5831132 0.81 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
SCHEMBL19917504 0.81 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
SCHEMBL3031149 0.81 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
SCHEMBL2921529 0.79 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
SCHEMBL195563 0.79 KMT2A (0.59) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
SCHEMBL5831401 0.79 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
Allylbenzene SCHEMBL28033498 0.77 MAOB (0.46) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
Hydrogen Peroxide SCHEMBL7816450 0.77 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
Hydrogen Peroxide SCHEMBL5496256 0.77 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15
SCHEMBL173301 0.76 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2CYP3A4TP53ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7572938-B2 Precursors for ketones and aldehydes GIVAUDAN SA (CH) 2009-08-11 US disclosed
US-20040171516-A1 Precursors for ketones and aldehydes GIVAUDAN SA (CH) 2004-09-02 US disclosed
EP-1390337-A1 PRECURSORS FOR KETONES AND ALDEHYDES Givaudan SA (CH) 2004-02-25 EP disclosed
WO-2002096850-A1 PRECURSORS FOR KETONES AND ALDEHYDES GIVAUDAN SA (CH) 2002-12-05 WO disclosed
EP-1262473-A1 Precursors for fragrant ketones and fragrant aldehydes Givaudan SA (CH) 2002-12-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040171516-A1 Precursors for ketones and aldehydes PDK3, PDK4, AKR1C4 ALDH1A1 13/4885SMN1; SMN2 3263/4885CYP3A4 235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.