Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376122 | 0.85 | LMNA (0.73) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL7503985 | 0.84 | LMNA (0.72) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL26167674 | 0.82 | LMNA (0.70) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL2117995 | 0.81 | LMNA (0.68) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL1373850 | 0.81 | LMNA (0.68) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL10912364 | 0.78 | LMNA (0.64) | LMNAKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL7502947 | 0.78 | LMNA (0.64) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL18764357 | 0.78 | LMNA (0.64) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL5805731 | 0.77 | LMNA (0.62) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL10083704 | 0.76 | L3MBTL1 (0.62) | LMNAKMT2AMEN1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580857-B2 | Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy | AU JESSIE L-S (US) | 2013-11-12 | — | — | US | claimed |
| US-7625860-B2 | Methods and compositions for modulating cell proliferation and cell death | AU JESSIE L-S | 2009-12-01 | — | — | US | disclosed |
| US-20040010001-A1 | Methods and compositions for modulating cell proliferation and cell death | AU JESSIE L-S (US) | 2004-01-15 | — | — | US | disclosed |