Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | JAK1 | P23458 | 6/20 | 0.39 |
| ▸ | TYK2 | P29597 | 6/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153398 | 0.83 | EPHX2 (0.39) | JAK2NAMPTRPS6KB1AURKB | |
| SCHEMBL4556652 | 0.82 | CDC7 (0.31) | JAK2CYP2C9RPS6KB1AURKBPLAU | |
| SCHEMBL3149479 | 0.75 | EPHX2 (0.39) | NAMPT | |
| SCHEMBL3144720 | 0.73 | HDAC1 (0.39) | NAMPT | |
| SCHEMBL3144560 | 0.71 | NAMPT (0.40) | NAMPTPLAUMAPT | |
| SCHEMBL4564571 | 0.69 | JAK3 (0.41) | JAK3JAK2JAK1TYK2IRAK4 | |
| SCHEMBL3149495 | 0.68 | NAMPT (0.40) | NAMPTAURKARPS6KB1 | |
| SCHEMBL3153349 | 0.68 | NAMPT (0.40) | NAMPT | |
| SCHEMBL3144699 | 0.68 | NAMPT (0.39) | NAMPTAURKARPS6KB1 | |
| SCHEMBL4556459 | 0.67 | NPSR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133348-A1 | AMINOPYRIDINE DERIVATIVES | VANTIA LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |