Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 10/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564609 | 0.64 | CYP2A6 (0.35) | HRH4 | |
| SCHEMBL7859535 | 0.62 | HRH4 (0.46) | HRH4HRH3MEN1RAB9AKMT2A | |
| SCHEMBL6111637 | 0.61 | F10 (0.52) | — | |
| SCHEMBL4324479 | 0.61 | HRH4 (0.62) | PYGLHRH4HRH3HRH1MEN1 | |
| SCHEMBL29952897 | 0.59 | CYP2A6 (0.58) | HRH4HRH3HRH1MEN1RAB9A | |
| SCHEMBL286735 | 0.59 | CYP2A6 (0.58) | HRH4HRH3HRH1MEN1RAB9A | |
| SCHEMBL27518830 | 0.59 | GRIN2B (0.48) | PYGLHRH4HRH3MEN1RAB9A | |
| SCHEMBL9316701 | 0.59 | DAO (0.44) | PYGLHRH4HRH3MEN1RAB9A | |
| Dimethylformamide SCHEMBL27616463 | 0.59 | AKR1B1 (0.46) | PYGLHRH4HRH3MEN1RAB9A | |
| SCHEMBL8350520 | 0.58 | F7 (0.46) | HRH4HRH3MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010172-A2 | INDOLES AND BENZOIMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117401-A2 | INDOLES AND BENZOIMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-18 | — | — | WO | disclosed |