Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 3/20 | 0.38 |
| ▸ | PYGM | P11217 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316069 | 0.83 | DAO (0.44) | DAOPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9202281 | 0.81 | MTNR1A (0.51) | DAOPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9316760 | 0.80 | MTNR1A (0.54) | PDE4APDE4BPDE4CPDE4DLOXL2 | |
| SCHEMBL7859535 | 0.73 | HRH4 (0.46) | DAOF11F7F3LOXL2 | |
| SCHEMBL9200232 | 0.70 | MAOB (0.45) | PDE4APDE4BPDE4CPDE4DMTNR1A | |
| SCHEMBL560686 | 0.70 | TSHR (0.57) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL657357 | 0.70 | TSHR (0.57) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL22831445 | 0.70 | TSHR (0.57) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL9200230 | 0.69 | MTNR1A (0.40) | DAOPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL559712 | 0.69 | MTNR1A (0.48) | PDE4APDE4BPDE4CPDE4DMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278166-A | 4-amino-3-heteroaryl butyric acid compounds, compositions, and their use for treating disorders involving a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5214063-A | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5162364-A | Treatment of spastic and senescence disorders | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |