Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 2/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564727 | 0.93 | F11 (0.34) | MAPTF11KLKB1TAS1R3TAS1R1 | |
| SCHEMBL3810553 | 0.86 | F11 (0.43) | MAPTF11KLKB1POLBNPSR1 | |
| SCHEMBL3817241 | 0.86 | F11 (0.39) | MAPTF11KLKB1POLBNPSR1 | |
| SCHEMBL3820233 | 0.85 | MAPT (0.47) | MAPTTAS1R3TAS1R1TAS1R2ITGB2 | |
| SCHEMBL3816821 | 0.85 | BCL2 (0.41) | MAPTTAS1R3TAS1R1TAS1R2ITGB2 | |
| SCHEMBL3820067 | 0.81 | DRD1 (0.42) | MAPTF11KLKB1NPSR1ALDH1A1 | |
| SCHEMBL4563029 | 0.81 | GRM5 (0.39) | MAPTPOLBNPSR1KMT2AALDH1A1 | |
| SCHEMBL3813529 | 0.77 | F11 (0.40) | MAPTF11KLKB1NPSR1MEN1 | |
| SCHEMBL13719953 | 0.76 | F11 (0.39) | MAPTF11KLKB1ITGB2ICAM1 | |
| SCHEMBL3819985 | 0.76 | POLB (0.44) | ITGB2ICAM1ITGALPOLBBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |