Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.73 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.73 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.73 |
| ▸ | PARP1 | P09874 | 6/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 3/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11331905 | 0.88 | CSNK1A1 (0.59) | CSNK1A1TYRO3DYRK1BPARP1HCRTR1 | |
| SCHEMBL6825869 | 0.84 | CSNK1A1 (1.00) | CSNK1A1TYRO3DYRK1BPARP1NUDT1 | |
| Water SCHEMBL30473073 | 0.83 | CSNK1A1 (0.97) | CSNK1A1TYRO3DYRK1BPARP1NUDT1 | |
| SCHEMBL4564863 | 0.81 | CSNK1A1 (0.61) | CSNK1A1TYRO3DYRK1BPARP1NUDT1 | |
| SCHEMBL30471810 | 0.77 | BCAT2 (0.52) | PARP1BTKPDPK1KDM4EALDH1A1 | |
| SCHEMBL7592281 | 0.76 | CSNK1A1 (0.47) | CSNK1A1TYRO3DYRK1BHCRTR1HCRTR2 | |
| SCHEMBL10937921 | 0.76 | SMN1; SMN2 (0.53) | CSNK1A1TYRO3DYRK1BKDM4EALDH1A1 | |
| SCHEMBL14886293 | 0.76 | CSNK1A1 (0.54) | CSNK1A1TYRO3DYRK1BPARP1HCRTR1 | |
| SCHEMBL29483242 | 0.76 | NISCH (0.47) | CSNK1A1TYRO3DYRK1BKDM4EALDH1A1 | |
| SCHEMBL2011486 | 0.76 | NISCH (0.47) | CSNK1A1TYRO3DYRK1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |