Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.61 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.61 |
| ▸ | PARP1 | P09874 | 7/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29054844 | 0.88 | CSNK1A1 (0.50) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL6001368 | 0.82 | NISCH (0.52) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL4982702 | 0.81 | CSNK1A1 (0.44) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL4564865 | 0.81 | CSNK1A1 (0.73) | CSNK1A1TYRO3DYRK1BPARP1PDPK1 | |
| Hydrochloric Acid SCHEMBL29265356 | 0.80 | NISCH (0.50) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL20770802 | 0.79 | CSNK1A1 (0.66) | CSNK1A1TYRO3DYRK1BPARP1AURKA | |
| SCHEMBL14886293 | 0.77 | CSNK1A1 (0.54) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL28766417 | 0.77 | NISCH (0.47) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL6825869 | 0.76 | CSNK1A1 (1.00) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL9260794 | 0.76 | NISCH (0.46) | CSNK1A1TYRO3DYRK1BPARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |