Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673711 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4521261 | 0.82 | ALDH1A1 (0.52) | ALDH1A1HPGDHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4896130 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HPGDHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4532187 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HPGDHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4532269 | 0.76 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL11340384 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HPGDHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4520363 | 0.74 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2KDM4ELMNA | |
| SCHEMBL4523252 | 0.74 | HTT (0.52) | ALDH1A1HPGDHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4518839 | 0.71 | SMN1; SMN2 (0.47) | ALDH1A1HPGDHSD17B10SMN1; SMN2ALOX15 | |
| SCHEMBL4531554 | 0.70 | ALDH1A1 (0.48) | ALDH1A1HPGDSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498334-B2 | Pyrrolopyrimidines as phosphodiesterase VII inhibitors | MERCK PATENT GMBH (DE) | 2009-03-03 | — | — | US | disclosed |
| US-20050059686-A1 | Pyrrolopyrimidines as phosphodiesterase vII inhibitors | MERCK PATENT GESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059686-A1 | Pyrrolopyrimidines as phosphodiesterase vII inhibitors | PDE5A, PDE3B, PDE4A | ALDH1A1 1713/4885HPGD 991/4885HSD17B10 2441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.