Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4520363 | 0.87 | ALDH1A1 (0.53) | HTTKDM4ERXFP1NPSR1MAPK1 | |
| SCHEMBL4760669 | 0.84 | HTT (0.44) | HTTKDM4ERXFP1NPSR1MAPK1 | |
| SCHEMBL4532269 | 0.82 | ALDH1A1 (0.51) | HTTKDM4ERXFP1NPSR1MAPK1 | |
| SCHEMBL4531554 | 0.81 | ALDH1A1 (0.48) | KDM4EMAPK1MEN1KMT2ALMNA | |
| SCHEMBL3259352 | 0.79 | KDM4E (0.56) | KDM4ERXFP1NPSR1MAPK1MEN1 | |
| SCHEMBL4518839 | 0.77 | SMN1; SMN2 (0.47) | KDM4ENPSR1MAPK1MEN1KMT2A | |
| SCHEMBL4564935 | 0.74 | ALDH1A1 (0.70) | HTTKDM4ERXFP1NPSR1MAPK1 | |
| SCHEMBL28800116 | 0.72 | GABRA2 (0.52) | HTTKDM4EMAPK1MEN1KMT2A | |
| SCHEMBL29800446 | 0.72 | GABRA2 (0.52) | HTTKDM4EMAPK1MEN1KMT2A | |
| SCHEMBL2680052 | 0.71 | LMNA (0.46) | HTTKDM4ERXFP1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498334-B2 | Pyrrolopyrimidines as phosphodiesterase VII inhibitors | MERCK PATENT GMBH (DE) | 2009-03-03 | — | — | US | disclosed |
| US-20050059686-A1 | Pyrrolopyrimidines as phosphodiesterase vII inhibitors | MERCK PATENT GESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059686-A1 | Pyrrolopyrimidines as phosphodiesterase vII inhibitors | PDE5A, PDE3B, PDE4A | HTT 4721/4885KDM4E 847/4885RXFP1 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.