Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KHK | P50053 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478245 | 0.87 | HRH3 (0.48) | HRH1HRH3 | |
| SCHEMBL4481591 | 0.87 | HRH1 (0.42) | HRH1HTR2C | |
| SCHEMBL4484620 | 0.85 | HTR2A (0.41) | HRH1SLC6A2SLC6A3HTR1AHTR2A | |
| SCHEMBL3799816 | 0.70 | TSHR (0.52) | HRH1HRH3 | |
| SCHEMBL19023362 | 0.68 | HRH1 (0.56) | HRH1HRH3KHKSLC6A2SLC6A3 | |
| SCHEMBL24437475 | 0.68 | HRH1 (1.00) | HRH1GBA1KHKSLC6A2SLC6A3 | |
| SCHEMBL12420648 | 0.68 | HRH1 (0.82) | HRH1GBA1HRH3KHKSLC6A2 | |
| SCHEMBL12735765 | 0.68 | HRH1 (0.61) | HRH1SLC6A2SLC6A3HTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL2195506 | 0.67 | HRH1 (0.59) | HRH1SLC6A2SLC6A3HTR1AHTR2C | |
| SCHEMBL4335524 | 0.67 | AR (0.40) | HRH1SLC6A2SLC6A3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039431-A2 | SUBSTITUTED ARYL-FUSED SPIROCYCLIC AMINES | NEUROGEN CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |