Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MLNR | O43193 | 2/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564958 | 0.87 | HRH1 (0.50) | HRH1HTR2C | |
| SCHEMBL4478245 | 0.85 | HRH3 (0.48) | HRH1CCR3 | |
| SCHEMBL3768437 | 0.71 | OPRK1 (0.51) | HRH1OPRK1CCR3 | |
| SCHEMBL19023393 | 0.69 | OPRK1 (0.52) | HRH1OPRK1SLC5A7MEN1KMT2A | |
| SCHEMBL5931995 | 0.68 | OPRK1 (0.51) | HRH1OPRK1CCR3SLC5A7MEN1 | |
| SCHEMBL3612680 | 0.68 | OPRK1 (0.54) | HRH1OPRK1SLC5A7MEN1KMT2A | |
| SCHEMBL25186260 | 0.68 | HRH3 (0.49) | HRH1CCR3NPC1 | |
| SCHEMBL4485943 | 0.67 | HRH3 (0.45) | HRH1CCR3MEN1KMT2A | |
| SCHEMBL19610351 | 0.67 | FAAH (0.52) | LMNANPC1 | |
| SCHEMBL5271411 | 0.67 | EPHX2 (0.59) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039431-A2 | SUBSTITUTED ARYL-FUSED SPIROCYCLIC AMINES | NEUROGEN CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |