Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574510 | 0.90 | PIK3CB (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGADAM17 | |
| SCHEMBL4730678 | 0.90 | PIK3CB (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGADAM17 | |
| SCHEMBL4572916 | 0.90 | PIK3CB (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGADAM17 | |
| SCHEMBL3987968 | 0.80 | JAK2 (0.51) | PIK3CAPIK3CBPIK3CDPIK3CGPDGFRB | |
| SCHEMBL4523399 | 0.79 | PIK3CB (0.67) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4607302 | 0.79 | PIK3CB (0.66) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4728682 | 0.78 | TERT (0.43) | PIK3CAPIK3CBPIK3CDPIK3CGTERT | |
| SCHEMBL4564983 | 0.78 | PIK3CD (0.40) | PIK3CAPIK3CBPIK3CDPIK3CGLMNA | |
| SCHEMBL4564984 | 0.76 | AKT1 (0.36) | PIK3CAPIK3CBPIK3CDPIK3CGLMNA | |
| SCHEMBL4570039 | 0.75 | AKT1 (0.37) | PIK3CAPIK3CBPIK3CDPIK3CGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057147-A1 | PYRIMIDINE DERIVATIVES | Astra Zeneca AB (SE) | 2009-05-13 | — | — | EP | claimed |
| WO-2008032064-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |