Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371554 | 0.80 | FGFR2 (0.48) | FGFR2KDRSRCTGFBR1PDGFRB | |
| SCHEMBL4591188 | 0.80 | FGFR2 (0.51) | FGFR2SRCTGFBR1PDGFRBPDGFRA | |
| SCHEMBL3105376 | 0.76 | AXL (0.46) | FGFR2METKDRPDGFRBPDGFRA | |
| SCHEMBL1791452 | 0.75 | PDGFRA (0.52) | FGFR2METKDRMST1RSRC | |
| SCHEMBL371529 | 0.74 | MET (0.47) | METKDRMST1RSRCTGFBR1 | |
| SCHEMBL371690 | 0.74 | MET (0.51) | FGFR2METKDRMST1RAXL | |
| SCHEMBL13210983 | 0.73 | MET (0.54) | METKDRMST1RSRCTGFBR1 | |
| SCHEMBL371825 | 0.73 | MET (0.76) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL10242715 | 0.73 | FGFR2 (0.43) | FGFR2METKDRSRCTGFBR1 | |
| SCHEMBL13739661 | 0.72 | SRC (0.60) | FGFR2METKDRMST1RSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |