SCHEMBL4565078

SCHEMBL4565078

C#CCn1c(-c2ccccc2C(OF)O[Si](C(C)C)(C(C)C)C(C)C)c(C2CCCCC2)c2c(C)cc(C(=O)O)cc21

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 1/20 0.31
MMP12 P39900 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3598982 0.79 PRKCA (0.37) PRKCAMMP12
SCHEMBL3589881 0.77 VDR (0.33)
SCHEMBL3593841 0.72 PTGDR2 (0.33)
SCHEMBL3590122 0.66 PRKCA (0.37) PRKCAMMP12
SCHEMBL14567296 0.61 PRKCA (0.39) PRKCAMMP12
SCHEMBL3586034 0.61 PRKCA (0.38) PRKCAMMP12
SCHEMBL3596365 0.61 PRKCA (0.40) PRKCAMMP12
SCHEMBL3582552 0.60 KCNH2 (0.39)
SCHEMBL3596844 0.60 PRKCA (0.39) PRKCAMMP12
SCHEMBL14110707 0.60 HTR2C (0.36) PRKCAMMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2027125-A1 PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) 2009-02-25 EP disclosed
WO-2007129119-A1 PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2007-11-15 WO disclosed