Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11195005 | 0.85 | NOTUM (0.45) | NOTUMS1PR1HAO1HSP90AA1GAA | |
| SCHEMBL11201412 | 0.83 | S1PR1 (0.44) | NOTUMS1PR1HAO1HSP90AA1GAA | |
| SCHEMBL11203285 | 0.83 | S1PR1 (0.44) | NOTUMS1PR1HAO1HSP90AA1GAA | |
| SCHEMBL11195134 | 0.76 | NOTUM (0.33) | NOTUMS1PR1HAO1 | |
| SCHEMBL7249097 | 0.68 | ESR2 (0.52) | — | |
| SCHEMBL29097441 | 0.68 | ALDH1A1 (0.41) | MAPT | |
| SCHEMBL780217 | 0.67 | SLC18A3 (0.43) | GAAMAPT | |
| SCHEMBL4943496 | 0.66 | DGAT1 (0.40) | NOTUM | |
| SCHEMBL20048272 | 0.65 | GRM5 (0.44) | GAAMAPT | |
| SCHEMBL8815392 | 0.65 | HRH3 (0.62) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | disclosed |