Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561588 | 0.84 | POLB (0.40) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL949704 | 0.78 | EGFR (0.46) | GAAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL20524577 | 0.77 | POLB (0.47) | POLBTDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL30989958 | 0.75 | POLB (0.68) | POLBTDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL5780074 | 0.75 | POLB (0.68) | POLBTDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL5013567 | 0.74 | NNMT (0.54) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL29903108 | 0.74 | NNMT (0.54) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL2027363 | 0.74 | PDCD1 (0.52) | POLBTDP1GAAALDH1A1KDM4E | |
| SCHEMBL17607728 | 0.72 | ALDH1A1 (0.42) | GAARECQLALDH1A1KDM4EMAPT | |
| SCHEMBL13035848 | 0.71 | PLK1 (0.45) | POLBTDP1GAARECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634424-B2 | Diazaindole derivative and use thereof as CHK1 inhibitor | MEDSHINE DISCOVERY INC. (CN) | 2023-04-25 | — | — | US | disclosed |
| US-20230017858-A1 | DIAZAINDOLE DERIVATIVE AND USE THEREOF AS CHK1 INHIBITOR | Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. (CN) | 2023-01-19 | — | — | US | disclosed |
| WO-2021104461-A1 | DIAZAINDOLE DERIVATIVE AND USE THEREOF AS CHK1 INHIBITOR | 南京明德新药研发有限公司 | 2021-06-03 | — | — | WO | disclosed |
| US-9067920-B2 | Compounds useful for inhibiting Chk1 | ELI LILLY AND COMPANY (US) | 2015-06-30 | — | — | US | disclosed |
| EP-2638033-B1 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | LILLY CO ELI (US) | 2015-04-08 | — | — | EP | disclosed |
| EP-2638033-A1 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | Eli Lilly and Company (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20130190262-A1 | Compounds Useful for Inhibiting Chk1 | ELI LILLY AND COMPANY (US) | 2013-07-25 | — | — | US | disclosed |
| WO-2012064548-A1 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | ELI LILLY AND COMPANY (US) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230017858-A1 | DIAZAINDOLE DERIVATIVE AND USE THEREOF AS CHK1 INHIBITOR | CHEK1, CHEK2, DDB1 | POLB 142/4885TDP1 168/4885GAA 2460/4885 |
| US-11634424-B2 | Diazaindole derivative and use thereof as CHK1 inhibitor | CHEK1, CHEK2, DDB1 | POLB 142/4885TDP1 168/4885GAA 2460/4885 |
| US-20130190262-A1 | Compounds Useful for Inhibiting Chk1 | CHEK1, CHEK2, PLK1 | POLB 343/4885TDP1 288/4885GAA 3305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.