Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 9/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565265 | 1.00 | MAPT (0.63) | MAPTRAB9APKMNPC1PAX8 | |
| SCHEMBL13709151 | 0.87 | MEN1 (0.72) | MAPTRAB9AMEN1KMT2APOLB | |
| SCHEMBL3340347 | 0.87 | KMT2A (0.69) | MAPTRAB9APKMNPC1MEN1 | |
| SCHEMBL4445674 | 0.86 | MEN1 (0.68) | MAPTRAB9APKMNPC1PAX8 | |
| SCHEMBL13709154 | 0.85 | ALOX5 (0.53) | MAPTRAB9APKMNPC1PAX8 | |
| Hydrochloric Acid SCHEMBL2105315 | 0.85 | MEN1 (0.67) | MAPTRAB9APKMNPC1PAX8 | |
| SCHEMBL16502313 | 0.84 | MAPT (0.59) | MAPTRAB9APKMNPC1PAX8 | |
| SCHEMBL7122886 | 0.84 | RORC (0.77) | MAPTRAB9APKMNPC1PAX8 | |
| SCHEMBL13709102 | 0.83 | AKR1B1 (0.69) | MAPTLMNAPPARG | |
| SCHEMBL13709106 | 0.83 | MAPT (0.58) | MAPTRAB9APKMNPC1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112615-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING THE TRANSCRIPTION FACTOR INDUCIBLE BY HYPOXIA, MODULATORS OF PATHOLOGICAL PROCESSES OF ANGIOGENESIS, ONCOGENESIS, INFLAMMATION, APOPTOSIS, AND CELLULAR THERAPY | FUNDACIÓN DE LA COMUNIDAD VALENCIANA, CENTRO DE INVESTIGACIÓN PRINCIPE FELIPE (ES) | 2009-09-17 | — | — | WO | disclosed |