Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 19/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 10/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19798753 | 0.80 | EPHX2 (0.64) | EPHX2EPHX1HSD11B1 | |
| SCHEMBL5146687 | 0.78 | EPHX1 (1.00) | EPHX2EPHX1 | |
| SCHEMBL19798751 | 0.77 | EPHX2 (0.60) | EPHX2EPHX1HSD11B1 | |
| SCHEMBL19798752 | 0.77 | EPHX2 (0.60) | EPHX2EPHX1HSD11B1 | |
| SCHEMBL19798749 | 0.76 | EPHX2 (0.61) | EPHX2EPHX1HSD11B1 | |
| SCHEMBL20724718 | 0.73 | EPHX2 (0.55) | EPHX2EPHX1HSD11B1 | |
| SCHEMBL5146628 | 0.71 | EPHX2 (1.00) | EPHX2EPHX1 | |
| SCHEMBL4215609 | 0.71 | HSD11B1 (0.56) | EPHX2HSD11B1 | |
| SCHEMBL17875052 | 0.70 | EPHX2 (0.70) | EPHX2EPHX1 | |
| SCHEMBL25358145 | 0.67 | L3MBTL1 (0.68) | EPHX2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029539-A1 | PIPERIDINYL, INDOLYL, PIRINIDYL, MORPHOLINYL AND BENZIMIDAZOLYL UREA DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE FOR THE TREATMENT OF HYPERTENSION, INFLAMMATIONS AND OTHER DISEASES | The Regents of the University of California (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007106525-A1 | PIPERIDINYL, INDOLYL, PIRINIDYL, MORPHOLINYL AND BENZIMIDAZOLYL UREA DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE FOR THE TREATMENT OF HYPERTENSION, INFLAMMATIONS AND OTHER DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-09-20 | — | — | WO | disclosed |