SCHEMBL4565809

SCHEMBL4565809

CCCC[C@H](NNC(=O)COc1ccc(C(N)(C(=O)OCC2c3ccccc3-c3ccccc32)c2ccc(OC)cc2OC)cc1)C(=O)NC(c1ccccc1)c1ccc(C)cc1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.40
▸ KMT2A Q03164 5/20 0.40
▸ MDM2 Q00987 3/20 0.35
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ ALDH1A1 P00352 3/20 0.33
▸ LMNA P02545 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ HPGD P15428 2/20 0.33
▸ HTT P42858 2/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ TLR2 O60603 2/20 0.32
▸ PTPN1 P18031 1/20 0.32
▸ ADAMTS5 Q9UNA0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31194380 0.90 MDM2 (0.40) MEN1KMT2AMDM2NPC1RAB9A
SCHEMBL29385536 0.90 KMT2A (0.43) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL29521535 0.89 MEN1 (0.49) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL8079493 0.82 MEN1 (0.40) MEN1KMT2AMDM2NPC1RAB9A
SCHEMBL30679137 0.80 NPC1 (0.44) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL20973955 0.79 NPC1 (0.40) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL27082137 0.78 NPC1 (0.40) MEN1KMT2AMDM2NPC1RAB9A
SCHEMBL8752790 0.78 NPC1 (0.41) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL28191790 0.77 NPC1 (0.39) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL28069714 0.76 FABP5 (0.45) MEN1KMT2AMDM2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4604986-A2 LONG-ACTING NATRIURETIC PEPTIDES AND USES THEREOF Eli Lilly and Company (US) 2025-08-27 — — EP disclosed
WO-2024086680-A2 LONG-ACTING NATRIURETIC PEPTIDES AND USES THEREOF ELI LILLY AND COMPANY (US) 2024-04-25 — — WO disclosed
EP-1789436-B1 ANTIBACTERIAL PEPTIDES AND ANALOGUES THEREOF UNIV SIENA (IT) 2009-12-16 — — EP disclosed
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