Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565933 | 1.00 | HPGD (0.39) | HPGDMAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL964295 | 0.89 | HPGD (0.36) | HPGDMAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL964296 | 0.89 | HPGD (0.36) | HPGDMAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL963440 | 0.84 | NR3C1 (0.37) | HPGDMAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL963441 | 0.84 | NR3C1 (0.37) | HPGDMAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL968579 | 0.82 | PPARG (0.37) | HPGDMAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL963031 | 0.82 | ENPP3 (0.43) | MAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL963030 | 0.82 | ENPP3 (0.43) | MAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL968581 | 0.82 | PPARG (0.37) | HPGDMAPTNR2F2HTTSMN1; SMN2 | |
| SCHEMBL962628 | 0.81 | PPARG (0.41) | MAPTNR2F2HTTSMN1; SMN2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |