Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3305065 | 0.85 | NR1H2 (0.53) | NR1H2 | |
| SCHEMBL3309831 | 0.80 | GRM2 (0.38) | HPGDKDM4EALDH1A1HSD17B10NR1H2 | |
| SCHEMBL27830572 | 0.77 | ACLY (0.47) | TDO2NTRK1MAPT | |
| SCHEMBL3301415 | 0.72 | NR1H2 (0.53) | NR1H2APP | |
| SCHEMBL31196173 | 0.71 | AOC3 (0.47) | HPGDALDH1A1HSD17B10ABL1 | |
| SCHEMBL17674258 | 0.70 | KDM4E (0.46) | HPGDKDM4EALDH1A1HSD17B10ABL1 | |
| SCHEMBL17674201 | 0.69 | NTRK1 (0.48) | HPGDKDM4EALDH1A1HSD17B10NTRK1 | |
| SCHEMBL4054875 | 0.69 | KDM4E (0.53) | HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL17674413 | 0.68 | KDM4E (0.43) | HPGDKDM4EALDH1A1HSD17B10NTRK1 | |
| SCHEMBL4437497 | 0.67 | NR1H2 (0.51) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121655-A1 | NOVEL 2-HETEROARYL SUBSTITUTED INDOLES 695 | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008108729-A1 | NOVEL 2-HETEROARYL SUBSTITUTED INDOLES 695 | ASTRAZENECA AB (SE) | 2008-09-12 | — | — | WO | disclosed |