Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2076854 | 0.87 | KDR (0.48) | KDR | |
| SCHEMBL2078386 | 0.87 | TSHR (0.51) | TSHRMAPK14 | |
| SCHEMBL27472808 | 0.83 | TSHR (0.52) | TSHRMAPK14 | |
| SCHEMBL2076844 | 0.77 | L3MBTL1 (0.40) | KDR | |
| SCHEMBL2862025 | 0.77 | TSHR (0.55) | TSHRMAPK14 | |
| SCHEMBL7811465 | 0.76 | MAPK14 (0.43) | MAPK14 | |
| SCHEMBL3173105 | 0.74 | TSHR (0.44) | TSHR | |
| SCHEMBL4354692 | 0.73 | TSHR (0.43) | TSHR | |
| SCHEMBL5499546 | 0.73 | TSHR (0.56) | TSHRMAPK14 | |
| SCHEMBL28036519 | 0.72 | MAPK14 (0.46) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024360-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | Cephalon, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |