Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078237 | 0.87 | BTK (0.33) | TSHRALDH1A1LMNA | |
| SCHEMBL2077100 | 0.87 | TSHR (0.54) | TSHRRIPK2ALDH1A1LMNARAB9A | |
| SCHEMBL27714943 | 0.75 | ALDH1A1 (0.42) | TSHRRIPK2ALDH1A1LMNARAB9A | |
| SCHEMBL27714942 | 0.75 | ALDH1A1 (0.33) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL27715082 | 0.74 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL27714945 | 0.74 | ALDH1A1 (0.44) | TSHRRIPK2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5499546 | 0.69 | TSHR (0.56) | TSHRRIPK2ALDH1A1LMNARAB9A | |
| SCHEMBL27106085 | 0.69 | NPC1 (0.61) | TSHRALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4350697 | 0.68 | PKM (0.41) | — | |
| SCHEMBL10389112 | 0.68 | TSHR (0.37) | TSHRRIPK2ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024360-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | Cephalon, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |