Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 15/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 15/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301313 | 0.95 | KEAP1 (0.39) | KEAP1NFE2L2SMN1; SMN2TP53PLAU | |
| SCHEMBL3298596 | 0.90 | KEAP1 (0.38) | KEAP1NFE2L2SMN1; SMN2TP53 | |
| SCHEMBL3298273 | 0.88 | KEAP1 (0.39) | KEAP1NFE2L2SMN1; SMN2TP53 | |
| SCHEMBL3300107 | 0.88 | KEAP1 (0.38) | KEAP1NFE2L2SMN1; SMN2TP53 | |
| SCHEMBL10322457 | 0.85 | KEAP1 (0.35) | KEAP1NFE2L2SMN1; SMN2TP53 | |
| SCHEMBL13390531 | 0.84 | PKM (0.35) | SMN1; SMN2TP53 | |
| SCHEMBL4432779 | 0.81 | KEAP1 (0.35) | KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL3301072 | 0.81 | KEAP1 (0.39) | KEAP1NFE2L2SMN1; SMN2TP53 | |
| SCHEMBL13391104 | 0.80 | KEAP1 (0.33) | KEAP1NFE2L2SMN1; SMN2PLAU | |
| SCHEMBL13390573 | 0.80 | PKM (0.35) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |
| EP-2121600-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008099000-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |