Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 10/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555203 | 0.83 | EGLN1 (0.38) | — | |
| SCHEMBL4855306 | 0.81 | NR3C1 (0.35) | — | |
| SCHEMBL4810475 | 0.81 | TTK (0.31) | — | |
| SCHEMBL4866562 | 0.80 | HSP90AA1 (0.34) | — | |
| SCHEMBL4564249 | 0.80 | NR3C1 (0.31) | — | |
| SCHEMBL4555633 | 0.80 | PGR (0.38) | — | |
| SCHEMBL4628879 | 0.80 | MAPT (0.36) | SMN1; SMN2 | |
| SCHEMBL4564230 | 0.79 | MAPT (0.36) | SMN1; SMN2 | |
| SCHEMBL4865539 | 0.79 | CYP19A1 (0.34) | — | |
| SCHEMBL4556232 | 0.79 | CYP19A1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125825-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079139-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |