SCHEMBL456626

SCHEMBL456626

CO[C]1CC(c2ccccc2)=CC=C1Br

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.35
HTR2C P28335 1/20 0.34
PDE4B Q07343 3/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
MAPT P10636 2/20 0.32
KDM4E B2RXH2 1/20 0.32
HSD11B1 P28845 2/20 0.31
LTA4H P09960 1/20 0.31
CA4 P22748 1/20 0.31
BACE1 P56817 1/20 0.31
MEN1 O00255 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
PDE4A P27815 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31
ALDH1A1 P00352 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL458387 0.79 ALDH1A1 (0.33) PDE4BMAPTLTA4HCA4MEN1
SCHEMBL457120 0.79 MAPK10 (0.33) PDE4BMAPTLTA4HCA4BACE1
SCHEMBL457299 0.75 PDE4D (0.33) PDE4BPDE4DALDH1A1
SCHEMBL457003 0.72 ALDH1A1 (0.33) SIGMAR1ALDH1A1MAPK1
SCHEMBL455837 0.71 SHMT2 (0.33) ALDH1A1MAPK1
SCHEMBL3982745 0.71 ALDH1A1 (0.47) SIGMAR1HTR2CNPC1RAB9AMAPT
SCHEMBL7813226 0.66 MEN1 (0.35) PDE4BMAPTKDM4EHSD11B1CA4
SCHEMBL21625337 0.65 NPC1 (0.45) NPC1RAB9AMAPTKDM4EHSD11B1
SCHEMBL455340 0.64 TP53 (0.31) ALDH1A1MAPK1
SCHEMBL457777 0.64 ALDH1A1 (0.33) SIGMAR1ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2614053-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-07-17 EP disclosed
WO-2012033225-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-03-15 WO disclosed