Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | DCK | P27707 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536313 | 0.83 | FASN (0.63) | FASNALDH1A1L3MBTL1 | |
| SCHEMBL4536955 | 0.79 | FASN (0.58) | FASNALDH1A1L3MBTL1 | |
| SCHEMBL4540756 | 0.77 | FASN (0.52) | FASN | |
| SCHEMBL4533587 | 0.76 | FASN (0.47) | FASNMMP2ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL22206676 | 0.75 | FASN (0.48) | FASNDCK | |
| SCHEMBL22206674 | 0.75 | FASN (0.48) | FASN | |
| SCHEMBL4538564 | 0.75 | FASN (0.55) | FASNMMP2ALDH1A1L3MBTL1 | |
| SCHEMBL15544411 | 0.74 | SIGMAR1 (0.52) | FASNALDH1A1 | |
| SCHEMBL4562483 | 0.74 | FASN (0.55) | FASN | |
| SCHEMBL14720314 | 0.73 | SIGMAR1 (0.56) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |