Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19425897 | 0.81 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL6101023 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL13878053 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EMAPTMAPK1 | |
| SCHEMBL6925572 | 0.77 | LMNA (0.58) | ALDH1A1HPGDLMNAPTGESDNMT3A | |
| SCHEMBL607042 | 0.77 | LMNA (0.58) | ALDH1A1HPGDLMNAPTGESDNMT3A | |
| SCHEMBL29393294 | 0.77 | LMNA (0.58) | ALDH1A1HPGDLMNAPTGESDNMT3A | |
| SCHEMBL6101108 | 0.73 | MAPT (0.39) | ALDH1A1HPGDMAPTMAPK1TDP1 | |
| SCHEMBL6101116 | 0.73 | MAPT (0.39) | ALDH1A1HPGDMAPTMAPK1TDP1 | |
| SCHEMBL4368104 | 0.73 | KDM4E (0.66) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL13923575 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026248-A2 | HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) | 2009-02-26 | — | — | WO | disclosed |