Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.60 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10082142 | 0.86 | DGAT1 (0.55) | DGAT1KCNH2SOAT1ADORA2ACYP2C9 | |
| SCHEMBL4561861 | 0.85 | DGAT1 (0.65) | DGAT1KCNH2SOAT1ADORA2ACYP2C9 | |
| SCHEMBL4560992 | 0.85 | DGAT1 (0.57) | DGAT1KCNH2SOAT1ADORA2ACYP2C9 | |
| SCHEMBL4560514 | 0.84 | DGAT1 (0.62) | DGAT1KCNH2SOAT1ADORA2ACYP2C9 | |
| SCHEMBL10147125 | 0.84 | DGAT1 (0.58) | DGAT1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL14235399 | 0.83 | DGAT1 (0.60) | DGAT1KCNH2SOAT1ADORA2ACYP2C9 | |
| SCHEMBL14128713 | 0.83 | DGAT1 (0.60) | DGAT1KCNH2SOAT1ADORA2ACYP2C9 | |
| SCHEMBL10147139 | 0.83 | ACACB (0.57) | DGAT1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL6995535 | 0.83 | DGAT1 (0.61) | DGAT1KCNH2SOAT1ADORA2ACYP2C9 | |
| SCHEMBL10147228 | 0.82 | DGAT1 (0.89) | DGAT1KCNH2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064569-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-05-18 | — | — | WO | disclosed |