Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752517 | 0.90 | CCR2 (0.56) | CCR2MAPTTP53MAPK1HTT | |
| SCHEMBL6753789 | 0.84 | CCR2 (0.53) | CCR2MAPTTP53ALDH1A1KMT2A | |
| SCHEMBL6753297 | 0.83 | ALDH1A1 (0.56) | CCR2MAPTALDH1A1KMT2ACNR2 | |
| SCHEMBL30121932 | 0.83 | ALDH1A1 (0.56) | CCR2MAPTALDH1A1KMT2ACNR2 | |
| SCHEMBL4539709 | 0.82 | ALDH1A1 (0.57) | CCR2MAPTTP53MAPK1ALDH1A1 | |
| SCHEMBL670091 | 0.79 | MAPT (0.52) | MAPTTP53MAPK1HTTATM | |
| SCHEMBL8687383 | 0.79 | CCR2 (0.62) | CCR2ABCB11 | |
| SCHEMBL6750687 | 0.78 | ALDH1A1 (0.53) | CCR2ALDH1A1CNR2 | |
| SCHEMBL6754276 | 0.78 | CCR9 (0.54) | CCR2TP53 | |
| SCHEMBL16235858 | 0.76 | CCR2 (0.59) | CCR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063495-A2 | SUBSTITUTED INDOLE AND ITS DERIVATIVES AS CANNABINOID MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2009-05-22 | — | — | WO | claimed |
| WO-2009063495-A2 | SUBSTITUTED INDOLE AND ITS DERIVATIVES AS CANNABINOID MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2009-05-22 | — | — | WO | disclosed |