SCHEMBL4566729

SCHEMBL4566729

Cc1ccccc1C1=Cc2ccccc2C1[Si](C)(C)C1C(c2ccccc2C)=Cc2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.38
NPC1 O15118 6/20 0.38
SMN1; SMN2 Q16637 6/20 0.38
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
GAA P10253 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
NPSR1 Q6W5P4 2/20 0.32
MEN1 O00255 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32
NFKB1 P19838 1/20 0.32
NFKB2 Q00653 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29897866 0.80 DRD2 (0.33) RAB9ANPC1SMN1; SMN2CASP3SENP8
SCHEMBL23141272 0.80 DRD2 (0.33) RAB9ANPC1SMN1; SMN2CASP3SENP8
SCHEMBL7036428 0.80 MAPT (0.38) RAB9ANPC1SMN1; SMN2CASP3SENP8
SCHEMBL9067405 0.78 PBRM1 (0.32) RAB9ANPC1SMN1; SMN2CASP3SENP8
SCHEMBL8675349 0.77 RAB9A (0.33) RAB9ANPC1SMN1; SMN2CASP3SENP8
SCHEMBL1453225 0.77 CYP11B1 (0.36) RAB9ANPC1SMN1; SMN2HPGDMEN1
SCHEMBL27450590 0.76 PBRM1 (0.33) RAB9ANPC1SMN1; SMN2CASP3SENP8
SCHEMBL7054721 0.75 CYP1A2 (0.36) GAAALDH1A1CYP1A2RXFP1
SCHEMBL5476789 0.75 CYP1A2 (0.39) CYP1A2
Hydrochloric Acid SCHEMBL7198818 0.75 TNKS2 (0.32) RAB9ANPC1SMN1; SMN2CASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2061827-A2 PRODUCTION OF BLOCKCOPOLYMERS BY AMORPHOUS POLYMER SEGMENT INTERCHANGE VIA METATHESIS Dow Global Technologies Inc. (US) 2009-05-27 EP disclosed
WO-2008027268-A2 PRODUCTION OF BLOCKCOPOLYMERS BY AMORPHOUS POLYMER SEGMENT INTERCHANGE VIA METATHESIS DOW GLOBAL TECHNOLOGIES INC. (US) 2008-03-06 WO disclosed
US-7312295-B2 Copolymers of ethylene and 1-heptene DOW GLOBAL TECHNOLOGIES INC. (US) 2007-12-25 US disclosed
US-20070037949-A1 Peak force at break per millimeter of film thickness of a blown film made of the copolymer satisfies a given relationship; packaging film with tear resistance, rupture resistance with good optical properties DOW GLOBAL TECHNOLOGIES LLC 2007-02-15 US disclosed
WO-1994028034-A9 SUPPORTED METALLOCENE CATALYST SYSTEMS FOR THE POLYMERIZATION OF OLEFINS, PREPARATION AND USE THEREOF EXXON CHEMICAL PATENTS INC (US) 1999-07-29 WO disclosed
EP-0705281-B1 SUPPORTED METALLOCENE CATALYST SYSTEMS FOR THE POLYMERIZATION OF OLEFINS, PREPARATION AND USE THEREOF EXXON CHEMICAL PATENTS INC (US) 1998-03-11 EP disclosed